In 1543 Burhan Nizam Shah made an alliance with Rama Rajah and Jamshid Qutb Shah, Sultan of Golkonda, and attacked the Adil Shah, whereupon Rama Rajah, taking advantage of the latter's troubles, sent Venkatadri to reduce Raichur and the Doab, "so that Beejapore, attacked at the same time by three powerful princes in three separate quarters, was full of danger and disorder."[305] True to the traditions of his predecessors, the new Sultan of Bijapur "called Assud Khan from Balgoan to his presence and demanded his advice on the alarming state of affairs," with the result that he patched up a peace with Burhan, making over to him the rich districts surrounding Sholapur, and sent ambassadors to arrange terms with Vijayanagar. This done, and the allies having retired, Asada Khan marched against the Qutb Shah of Golkonda, defeated him under the walls of his capital, and in a personal encounter grievously wounded him in the face with his sabre.[306]

The Portuguese at this period had been very active, and amongst other more or less successful enterprises the Governor, Affonso de Sousa, attacked the territory of the Rani of Bhatkal on the pretext that she had withheld tribute due to the king of Portugal, and wasted her country with fire and sword. Her city was burnt, the Hindus were slain in large numbers, and the Rani reduced to submission.

About the year 1544 -- the date is somewhat uncertain -- Sultan Burhan again attacked Ibrahim Adil at the instigation of Rama Rajah, but was completely defeated.

"The sultan (Ibrahim) after this victory growing haughty and imperious, treated the ambassadors of Nizam Shah in a contemptuous manner, and behaved tyrannically to his own subjects, putting to death many and severely punishing others of his principal nobility for slight offences, which occasioned disaffection to his government."

On Burhan again invading Bijapur territories, a party was formed to depose Ibrahim and raise to the throne his brother Abdullah. This prince, finding that the conspiracy had been discovered, fled for safety to Goa, where he was well received. But when Ibrahim promised certain provinces to the Portuguese if they would send Abdullah away to a place where he could no longer disturb the peace of the Bijapur territories, De Sousa accepted the conditions; receiving the gift of Salsette and Bardes for the crown of Portugal, and the whole of the vast treasures accumulated by Asada Khan at Belgaum as a personal present for himself. Having pocketed as much as he could of the bribe, however, he only took Abdullah as far as Cannanore and then brought him back to Goa; and when, at the end of the next year, De Castro succeeded De Sousa as Governor, the former refused to surrender the rebel prince. This duplicity placed the Sultan in great difficulty, and in February 1546 he executed a treaty of peace, one of the terms of which was that no person belonging either to the Dakhan, or to the territories of the Nizam Shah, or to those of the king of Vijayanagar, with certain others specially mentioned, should be permitted to have any communication with Abdullah or his family until the reply of the king of Portugal was received to an embassy which the Adil Shah proposed to send to him. There were other terms also, and these not being acted up to by the Portuguese, the Sultan in 1547 sent some troops into the provinces of Salsette and Bardes, which were driven out by the Viceroy after a stubborn fight.

De Castro then concluded treaties with Vijayanagar on the 19th September 1547, and with Ahmadnagar on the 6th October of the same year, by the former of which the Hindu king was secured in the monopoly of the Goa horse trade,[307] and by the latter a defensive alliance was cemented between the Portuguese and the Nizam Shah. This constituted a tripartite league against Bijapur.

Shortly afterwards a still more determined attack was made by the Bijapur troops against the mainlands of Goa, and in the battle which ensued one of the Adil Shah's principal generals was slain.

In 1548 the Viceroy concluded a more favourable arrangement with Bijapur and also with the Rani of Bhatkal.